Sex steroid hormones regulate cell survival, synaptic plasticity, and the global morphology of brain regions that support learning and memory. The Jacobs Lab explores the structural and functional changes in the human brain that occur in response to changing hormonal conditions. We pair brain imaging tools with endocrine assessments to study how endogenous and exogenous endocrine factors (e.g. neuroendocrine aging during menopause, use of hormone-based medications, and menstrual cycle-dependent changes) influence brain structure, function, and cognition.
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