Credit: Tony Mastres

About Us

Sex hormones are powerful neuromodulators of learning and memory. Foundational studies in rodents and nonhuman primates have established estrogen and progesterone’s influence within the central nervous system across a range of spatiotemporal scales. Yet, sex hormones’ influence on the structural and functional architecture of the human brain is largely unknown. The Jacobs Lab uses brain imaging, endocrine, and computational approaches to deepen our understanding of sex hormone action in the human brain. Major initiatives include the study of endocrine aging during the midlife transition to menopause, pharmacological studies of gonadal hormone suppression, and dense-sampling studies across the menstrual cycle. For a complete description of current projects head here.

Join the Jacobs Lab

Interested in joining the lab?

Volunteer for a Study The Jacobs Lab is seeking adults (ages 25-60) from the Santa Barbara area to participate in a study on hormones and cognition. Learn more here and contact us at